# KPV

The last three amino acids of a natural anti-inflammatory hormone. It calms inflammation in cells and in mice with colitis. FDA has found no record of it being given to people in a study.

Also called: Lys-Pro-Val, Alpha-MSH fragment 11-13
Source page: https://peplogue.com/peptides/kpv/
Updated: 2026-10-22. Not medical advice.

## How it works

- Where it acts: Thought to enter gut-lining and immune cells and dampen inflammatory signalling.
- What it changes: In mice with colitis, less gut inflammation.
- What people notice: No human data.

## What the evidence shows

- **Inflamed bowel**: Lab only. Cell and mouse studies only.
- **General anti-inflammatory**: Lab only. Cell and mouse studies only.

## Side effects and risks

- unknown: No human safety data. FDA says it lacks the information to judge.

Who should avoid it: Treat it as untested.

## How it has been given in studies

No human dose exists.

## Legal status

- United States: undefined. Advisers backed compounding in July 2026. FDA staff opposed it, and FDA had not acted by late September 2026.
- European Union: undefined
- Spain: undefined. Research peptide. No authorised medicine in Spain that we found (not individually checked in CIMA). Not lawful to sell to the public.
- Germany: undefined. Not approved in Germany. Selling it as a medicine without approval is a crime (AMG § 21, § 96); sold online only as 'research' products.
- France: undefined. No French authorisation found. Not named by ANSM, but its Jul 2026 alert says peptides bought outside the official circuit are illegal.
- Italy: undefined. No Italian authorisation found. Not lawful to sell to the public as a medicine. Research-grade vials online are unverified products.
- Netherlands: undefined. No Dutch marketing authorisation found. Selling it as a medicine without one is illegal per IGJ, even if labelled 'research use'.
- United Kingdom: undefined
- Canada: undefined
- Australia: undefined

## Questions people ask

**Does KPV work for gut inflammation?**

Only in cells and in mice with colitis, where it reduced gut inflammation. FDA has found no record of it being given to people in a study.

**Do oral KPV capsules work?**

Users report a calmer gut, usually from capsules, but the reports are very few and there is no human data to check them against.

**Is KPV safe?**

There are no human safety data, and FDA says it lacks the information to judge.

**Is KPV legal in the US?**

FDA advisers voted 8 to 6 in July 2026 to back compounding, but FDA staff opposed it and FDA had not acted by late September 2026.

## Sources

- FDA: bulk substances that may present significant safety risks: https://www.fda.gov/drugs/human-drug-compounding/certain-bulk-drug-substances-use-compounding-may-present-significant-safety-risks
- McDermott: July 2026 advisory committee votes: https://www.mcdermottlaw.com/insights/bulk-list-bound-pcac-backs-majority-of-peptides-in-two-day-public-meeting/