# BPC-157 A 15-amino-acid fragment of a protein found in stomach juice. In rats it speeds the healing of tendons, muscle and gut. No randomized human trial has published results, and more than 80% of the research comes from one group. Also called: Body Protection Compound, PL 14736, Wolverine stack (BPC-157 + TB-500) Source page: https://peplogue.com/peptides/bpc-157/ Updated: 2026-10-22. Not medical advice. ## How it works - Where it acts: No receptor has been identified. In animals it appears to boost new blood vessels and growth-factor and nitric-oxide signalling. - What it changes: In rats, faster healing of tendons, muscle and the gut lining. - What people notice: No controlled human trial has reported results. People report faster recovery, but placebo and natural healing can explain much of that. ## What the evidence shows - **Tendon, ligament and muscle injuries**: Lab only. A 2025 systematic review of sports-injury research found 35 preclinical studies and one human study. A randomized, placebo-controlled trial in 120 people with hamstring strains has been recruiting since February 2026. - **Knee pain, injected into the joint**: Early. One clinic reported on 12 patients with no comparison group. Most said the pain improved. - **Ulcers and inflamed bowel**: Lab only. Animal studies, plus two early ulcerative-colitis enema trials that never published full results. A 2015 safety trial of an oral form never reported results. - **General tissue healing**: Lab only. Animal studies only. ## Side effects and risks - unknown: No clinical safety data, as published reviews state. - unknown: It promotes new blood-vessel growth in animals. Nobody has tested whether that could help a tumor grow. - serious: Product quality is unverified. The US Department of Defense warns of contamination, and FDA cites the risk of immune reactions to impurities. Who should avoid it: Anyone with a history of cancer, competitive athletes, and anyone who cannot verify what is in the vial. ## How it has been given in studies No established human dose. The only published human uses were one-off injections by a doctor into the knee joint or bladder wall, and an intravenous safety test in two volunteers. Self-injections and capsules sold online have no controlled human data. ## Legal status - United States: undefined. Advisers backed compounding in July 2026. FDA staff opposed it, and FDA had not acted by late September 2026. Some states, including Ohio and Alabama, have tightened their own rules. - European Union: undefined - Spain: undefined. Neither AEMPS nor the EMA has approved BPC-157 as a medicine (El Confidencial, Aug 2026). No CIMA entry. Not lawful to sell to the public. - Germany: undefined. Not approved in Germany. Selling it as a medicine without approval is a crime (AMG § 21, § 96). Rezeptur use could not be confirmed. - France: undefined. Not authorised. Named in ANSM's Jul 2026 alert; about ten serious cases in France. ANSM: never use vials marked 'research use only'. - Italy: undefined. No Italian authorisation found. Listed by WADA under S0 (non-approved substances). Research vials sold online are unverified. - Netherlands: undefined. No marketing authorisation. Webshops sell it as 'research only', which IGJ says does not make it legal. Banned in sport (WADA S0). - United Kingdom: undefined - Canada: undefined. Named in a 2025 Health Canada advisory and its April 2026 warning. - Australia: undefined. Schedule 4 and Appendix D of the Poisons Standard since 1 June 2024: possession without authority is illegal. ## Questions people ask **Does BPC-157 actually work?** In rats it speeds the healing of tendons, muscle and gut, but no randomized human trial has published results. A 2025 systematic review of sports-injury research found 35 preclinical studies and one human study, and more than 80% of the research comes from one group. **Is BPC-157 legal?** In the US, FDA advisers voted 8 to 6 in July 2026 to back compounding, but FDA staff opposed it and FDA had not acted by late September 2026. In Australia it has been Schedule 4 and Appendix D since 1 June 2024, so possession without authority is illegal. Health Canada named it in a 2025 advisory and an April 2026 warning. **What are the side effects of BPC-157?** There are no clinical safety data. Users report headache, tiredness and redness at the injection site, a minority describe flat mood or anxiety, and product quality is unverified. **Can BPC-157 cause cancer?** Nobody knows. It promotes new blood-vessel growth in animals, nobody has tested whether that could help a tumor grow, and people with a history of cancer are advised to avoid it. **What is the Wolverine stack?** A nickname for BPC-157 taken together with TB-500, mostly for injury recovery. No controlled human trial of BPC-157 has reported results. ## Sources - Vasireddi et al. 2025: systematic review of BPC-157: https://pmc.ncbi.nlm.nih.gov/articles/PMC12313605/ - Pharmaceuticals 2025: critique of the BPC-157 evidence: https://www.mdpi.com/1424-8247/18/10/1451 - McDermott: July 2026 advisory committee votes: https://www.mcdermottlaw.com/insights/bulk-list-bound-pcac-backs-majority-of-peptides-in-two-day-public-meeting/ - McDermott: state and federal enforcement (24 Sep 2026): https://www.mcdermottlaw.com/?p=50381208 - ClinicalTrials.gov: BPC 157 for hamstring strain (NCT07437547): https://clinicaltrials.gov/study/NCT07437547 - Operation Supplement Safety (US Defense Department): BPC-157: https://www.opss.org/article/bpc-157-prohibited-peptide-and-unapproved-drug-found-health-and-wellness-products - nference preprint: BPC-157 use in US health records (Sep 2026): https://www.preprints.org/manuscript/202609.0501/v1 - Health Canada: think twice before injecting peptides bought online (9 Apr 2026): https://recalls-rappels.canada.ca/en/alert-recall/think-twice-injecting-peptides-bought-online-unauthorized-products-can-seriously-harm - TGA: scheduling decision for BPC-157 (May 2024): https://www.tga.gov.au/sites/default/files/2024-05/notice-final-decisions-amend-not-amend-current-poisons-standard-november-2023.pdf